NFL Week 3 Computer Picks and Best Bets

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There are 16 games on the NFL’s Week 3 card, with the Saints (-3) among the best bets against the spread, based on our projections. For more tips, including parlay possibilities, see below.

Check out this week’s NFL action on , where you can also add on NFL RedZone to track every game at once.

Best Week 3 Spread Picks

Philadelphia Eagles at New Orleans Saints

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Spread Favorite: New Orleans (-3)
  • Projected Winner & Margin: Saints by 23.3 points
  • TV Channel: FOX
  • Live Stream:
  • New England Patriots at New York Jets

  • Game Day: Sept. 19
  • Kickoff: 8:15 PM ET
  • Spread Favorite: New York (-6)
  • Projected Winner & Margin: Patriots by 11.8 points
  • TV Channel: Amazon Prime Video
  • Live Stream:
  • Washington Commanders at Cincinnati Bengals

  • Game Day: Sept. 23
  • Kickoff: 8:15 PM ET
  • Spread Favorite: Cincinnati (-7.5)
  • Projected Winner & Margin: Bengals by 25.2 points
  • TV Channel: ABC
  • Live Stream:
  • Jacksonville Jaguars at Buffalo Bills

  • Game Day: Sept. 23
  • Kickoff: 7:30 PM ET
  • Spread Favorite: Buffalo (-5.5)
  • Projected Winner & Margin: Bills by 22.9 points
  • TV Channel: ESPN
  • Live Stream:
  • Detroit Lions at Arizona Cardinals

  • Game Day: Sept. 22
  • Kickoff: 4:25 PM ET
  • Spread Favorite: Detroit (-3)
  • Projected Winner & Margin: Cardinals by 10.2 points
  • TV Channel: FOX
  • Live Stream:
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    Best Week 3 Total Picks

    Los Angeles Chargers vs. Pittsburgh Steelers

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Pick: Under 35.5
  • Projected Total: 27.0 points
  • TV Channel: CBS
  • Live Stream: |
  • Philadelphia Eagles vs. New Orleans Saints

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Pick: Over 49.5
  • Projected Total: 56.5 points
  • TV Channel: FOX
  • Live Stream:
  • Houston Texans vs. Minnesota Vikings

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Pick: Under 46
  • Projected Total: 40.5 points
  • TV Channel: CBS
  • Live Stream: |
  • Green Bay Packers vs. Tennessee Titans

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Pick: Over 38
  • Projected Total: 42.8 points
  • TV Channel: FOX
  • Live Stream:
  • Chicago Bears vs. Indianapolis Colts

  • Game Day: Sept. 22
  • Kickoff: 1:00 PM ET
  • Pick: Under 43.5
  • Projected Total: 38.8 points
  • TV Channel: CBS
  • Live Stream: |
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